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Dopamine release is mediated by voltage-gated calcium channels that trigger exocytosis of dopamine-filled vesicles into the synaptic cleft, where dopamine binds to its target receptors

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Cachexia as the oldest description of body wasting, the term having been coined in ancient Greece [4], is defined as a ‘complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass’