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B1a cells express germline-encoded natural IgM with little to no affinity maturation, resulting in IgM that is broadly specific and low-affinity for many self-antigens (including oxLDL)

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[DOI] [PubMed] [Google Scholar] 164.Sekino N., Kano M., Matsumoto Y., Sakata H., Murakami K., Toyozumi T., Otsuka R., Yokoyama M., Shiraishi T., Okada K., et al