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All conditions that give rise to megaloblastic changes have in common a disparity in the rate of synthesis or availability of the four immediate precursors of DNA: the deoxyribonucleoside triphosphates (dNTPs)—dA(adenine)TP and dG(guanine)TP (purines), dT(thymine)TP and dC(cytosine)TP (pyrimidines)

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Also, growth hormone levels drop as we get older, and there was interest in seeing if tweaking these levels might benefit older adults struggling with loss of bone and muscle mass and increases in body fat