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These data suggest that it is important to monitor the effects of air pollution and its specific components on the growing fetus as mitochondrial dysfunction has been implicated in a wide variety of brain-based diseases in which an environmental component is suspected, including psychiatric [97,98,99,100], neurodevelopmental [15], and neurodegenerative disorders [101]

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MPO catalyzes the formation of hypochlorous acid (HOCl) and contributes to generating long-lived oxidants like chloramines, detected in high concentrations in CF sputum (Witko-Sarsat et al., 1995)