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Liposomal formulations, PEG-PLGA nanoparticles, and dendrimer or polymer micelles have each prolonged plasma half-life and shielded riboflavin from rapid renal loss, while surface ligands—such as wheat-germ agglutinin, transferrin-mimic peptides, and BBB-shuttling sequences—enable active transcytosis across the blood–brain barrier (86–89)