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Figure 6 Discussion Epigenetic changes in host cells during COVID-19 have already been described and are associated with the regulation of the SARS-CoV-2 cycle ( ex vivo model, it was demonstrated that vitamin B12 favorably modulates, by methyl-dependent epigenetic mechanisms, the expression of inflammatory genes and the activity of metabolic and signaling pathways related to the hyperinflammation associated with COVID-19 forms that require hospitalization