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Thus, it is not surprising that in obese men with testosterone deficiency, long-term testosterone therapy with formulations that achieve physiological levels, along with adequate adherence, produced significant and sustained weight loss, concomitant with reduction in waist circumference and BMI (Table 2, Figs 1 and 2) [23 ▪▪ ,27–44,45 ▪ ,46 ▪▪ ,47–56,57 ▪ ,58 ▪▪ –61 ▪▪ ,62 ▪ ,63 ▪ ,64–66,72]