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Keywords: CD38, NADase, NAD+, antibodies, small molecules, SIRTUINs, aging, cancer and metabolism Emerging roles of NAD metabolism in human disease: The promise of “NAD boosting therapies” Nicotinamide adenine dinucleotide (NAD) is a cofactor in electron transfer during oxidation-reduction reactions, and also plays a crucial role in cell signaling, regulating several pathways from intracellular calcium transients to the epigenetic status of chromatin [1-6]

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