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It is also a cautionary illustration of how much context a mechanism carries: the best-characterized KPV effect depends on an intestinal transporter (PepT1) abundant in gut epithelium, which is one reason KPV has been explored mainly for oral delivery in bowel inflammation rather than as a general-purpose systemic anti-inflammatory
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Moreover, this targeted peptide (referred to as Ab 46 -D-Glu 20 henceforth) can be administered without detectable toxicity to healthy tissues or modification of healthy bones in dogs
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