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While early laboratory studies on the effect of iodine on the thyroid gland suggested that methimazole can inhibit somewhat the Wolff-Chaikoff effect (278-280), more recent clinical data indicates their ultimate impact on systemic thyroid hormone levels to be additive (281, 282)

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The popular Chinese herb, Chuen-Lin, given to 28% to 51% of Chinese newborn infants, has been shown to have a significant effect in displacing bilirubin from albumin