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The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 6–7% discontinued treatment due to AE, 34–44% experienced nausea, 21–32% diarrhoea and 22–25% vomiting) [11, 29]
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