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Based both on the oddity of non-metazoans having this isoform and the intimate intracellular interaction between these intracellular protozoan parasites and both their vertebrate and invertebrate metazoan hosts, lateral gene transfer from host to parasite seemed a plausible model for the appearance of this unexpected isoform outside of metazoans

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And conditions that lead to low stomach acid also lead to a myriad of nutrient deficiencies, including B12 deficiency