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Ask the Doctors - Are large doses of B12 safe? | UCLA Health

The initial outcome of the mitochondrial respiratory chain is the generation of O 2 •− , which is formed at numerous mitochondrial locations, encompassing NADH:ubiquinone oxidoreductase (complex I), succinate dehydrogenase (complex II), ubiquinol:cytochrome c oxidoreductase (complex III), and mitochondrial glycerol 3-phosphate dehydrogenase [15]

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[DOI] [PubMed] 157.Criado-Gonzalez M, Iqbal MH, Carvalho A, Schmutz M, Jierry L, Schaaf P