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A study on Ang II-induced vascular remodeling in mice showed that CD38 deficiency leads to elevated NAD levels, mitigating Ang II-induced vascular aging through VSMC aging inhibition (97)

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Increasing mitochondrial antioxidant defenses through treatment with the pharmacological mROS scavenger MnTBAP or genetic expression of mCAT blocks 2-E+2-3a induced activation of the NLRP3-I, which is absolutely dependent on the presence of mtDNA