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Health and Disease: Low levels of glutathione have been linked to several diseases, including cancer, neurodegenerative disorders such as Parkinson’s disease, cardiovascular diseases, and HIV/AIDS
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Recent experiments indicated a role for GPx4 in tumor angiogenesis by suppressing lipid peroxidation derived from 12/15-lipoxygenase activity or cycloxygenase-2 possibly via modulation of ROS sensitive tyrosine kinase signaling pathways (Heirman et al., 2006
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