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To study the molecular mechanisms of signal transduction pathways, the nematode Caenorhabditis elegans resulted to be a powerful animal model thanks to a completely sequenced genome and the 75% homology shared with that of mammals ( Furthermore, C

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In ROS-rich conditions, the microspheres released exosomes, lowered intracellular ROS and mitochondrial ROS, and suppressed MMP-13 and ADAMTS5 expression in vitro (Peng et al., 2025) (Figure 1D)