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Injection sites: Abdomen (2 inches from the navel, any direction) — PREFERRED Upper thighs (front or outer) Upper arms (outer aspect, if administered by an assistant) Rotate sites with each injection to prevent tissue irritation Why the abdomen is preferred: Higher subcutaneous fat content Better absorption Easier self-administration Less muscle tissue (reduces risk of intramuscular injection) Injection procedure: Prepare the site: Clean the area with an alcohol swab Let the alcohol dry completely (prevents stinging) Pinch the skin to create a fold of subcutaneous tissue Prepare the syringe: Draw the calculated dose from the vial Remove air bubbles by tapping the syringe Verify the correct dose Ensure the needle is sharp and sterile Administer the injection: Insert the needle at a 45–90 degree angle (depending on body fat thickness) Inject slowly and steadily over 3–5 seconds Withdraw the needle smoothly Apply gentle pressure if needed (do not rub) After the injection: Dispose of the needle safely in a sharps container Record injection site, dose, time, and date Monitor the site for any reactions Refrigerate the vial immediately Dosing Frequency and Timing The relatively short half-life of AOD9604 (2–4 hours) influences optimal dosing strategies

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Numerous studies have recently investigated the inhibitory effects of natural products on adipocyte differentiation and lipid accumulation