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By inhibiting NNMT, 5-Amino-1MQ prevents this NAD⁺ drain , allowing cells to maintain higher NAD⁺ availability

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Preclinical models demonstrate that these compounds reduce reactive oxygen species, stabilize mitochondrial membrane potential, enhance mitophagy, and activate NRF2 dependent transcription, which translates into attenuation of ASD like behaviors in VPA, propionic acid, maternal immune activation, and BTBR paradigms (De Mattos et al., 2020