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Whenever resonances were not sufficiently resolved (correlation coefficient r 40%) Ka: absorption rate constant, V: volume of distribution, F: oral bioavailability, CL: steady-state clearance, RUV: random unexplained variability, RSE: relative standard error, IIV: inter-individual variability Systemic measures of oxidative stress Blood catalase and GSH/GSSG, measures of anti-oxidant capacity, significantly increased after NAC dosing (p 100-fold)

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And the genetic risk, epigenetic influences and environmental factors must also interact and contribute to the onset and development of disease (Fig