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Zinc finger-inspired nanohydrogels with glutathione/pH triggered degradation based on coordination substitution for highly efficient delivery of anti-cancer drugs - ScienceDirect

(4) The activation of CYP1A1 actually increased the genetic toxicity on vessel-wall cells through the metabolism of BaP into BPDE, which can form DNA adducts and induce mutation (Figure 1)

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Thus, this can lead to an alteration of the antioxidant defence system, which, under normal conditions, balances peroxidation with the help of the production of glutathione, SOD and catalase, but, in the case of a higher rate of lipid peroxidation, the skin’s endogenous protective antioxidants are not sufficient [82]