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However, sibutramine and orlistat are associated with cardiovascular and GI side effects, respectively, which make them undesirable to both patients and physicians

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The 12-week GLOW protocol keeps that dose constant: 2.8 mg daily in weeks 1–4, 2.8 mg 5x per week in weeks 5–8, and 2.8 mg 2-3x per week for maintenance in weeks 9–12