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The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters — establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions
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![PDF] GLUTATHIONE AS A WHITENING AGENT IN THE TREATMENT OF MELANOSIS ON FACE](https://figures.semanticscholar.org/70a65bda2d4e75b33840b1b75dee60ea4f427c4f/4-Figure1-1.png)
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