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The integration of both imaging modalities, TEM and FESEM, together with EDS evidence, establishes that not only does the final BiNPs-NISM-Dox/Pi3Ki@BSA-GSH-Glu nanosystem contain a high payload incorporation, but it also possesses the capacity to maintain nanostructural and chemical integrity, the very basis of its encouraging biomedical promise
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In accordance, MCL-1 inhibitors have shown pre-clinical activity in AML 15,16 , and MCL-1 inhibition synergized with Venetoclax in AML models 17,18,19
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