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Since the production of γ-glutamyl peptides is elevated under certain pathological conditions, it is conceivable that they transmit signals from damaged cells to surrounding cells via the modulation of CaSR action

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Previous work suggests that hyperglycemia increases ΔΨ m , which leads to excess superoxide production through enhanced glycolytic flux and a surplus of electron carriers generated by the TCA cycle [321,322,323,324]