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In comparison to tretinoin, retinaldehyde appears to be more effective and better tolerated in anti-aging treatments for wrinkle reduction at concentrations of 0.05%.[] Retinaldehyde reduced the concentration of melanin in guinea pig ears and mouse tails by 54% and 74%, respectively, diminishing the count of active melanocytes by 42% and 77%, respectively.[] Studies demonstrating the effects of retinaldehyde in hyperpigmentary conditions are scarce
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