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Meanwhile, cGAS-STING senses mitochondrial DNA (mtDNA) released from damaged mitochondria during ferroptosis and drives the production of type I interferons (IFN-I), thereby regulating expression of TfR1 and recruiting immune cells to intensify tissue injury (132, 133)

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The severity of anemia exhibited dose- and duration-dependence, with maximum effects observed after approximately 3 weeks of exposure

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