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Concurrently, the activation of AMPK can modulate the expression of genes associated with circadian rhythm, such as DBP, PER3, and NFIL3 [74, 127]

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493 During the treatment of patients with moderate to severe UC, persistent intestinal emergencies improve and are relieved, rectal bleeding is significantly reduced, 494–496 and C-reactive protein and fecal calprotectin levels decrease to varying degrees