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found that knocking out ACSL4 does not affect cortical blood flow after middle cerebral artery occlusion/reperfusion (MCAO/R) in rats, but it reduces infarct volume and mitigates neural damage by inhibiting ferroptosis (Tuo et al., 2022)
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AMPK Activation & Metabolic Homeostasis MOTS-c targets the folate cycle to inhibit 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase (ATIC), leading to the accumulation of AICAR and subsequent phosphorylation of AMPK
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