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Despite the complexities and unresolved questions, further exploration of this pathway may not only advance the understanding of diabetic kidney injury but also reveal new therapeutic opportunities for managing DKD

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In mice, acute and chronic exposure for 30 days to a low dose of alcohol (0.5 grams per kilogram of body weight), corresponding to about two standard drinks per day for a human, improved glymphatic activity, whereas intermediate and high doses, corresponding to about eight and 21 drinks per day for a human, impaired glymphatic activity