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MT-1’s MC1R-preferential activity makes it the primary research tool for studying MC1R biology in pigmentation, photoprotection, and skin immunology without the confounding central melanocortin receptor activation that limits the interpretability of studies using less selective melanocortin agonists

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Bound interfaces of known neo-substrates (CK1α, Ikaros, ZNF692 and GSPT1) were queried against the AF2-predicted human proteome database