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Step 5 — Address oxidative stress and mitochondrial health Since oxidative stress impairs B12 trafficking into mitochondria and sustains the MMA feedback loop, mitochondrial antioxidant support matters alongside targeted B12

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The mTORC1 pathway (the mammalian target of rapamycin, mTOR and its downstream target, p70 ribosomal S6 kinase or p70S6K) is involved in nutrient sensing and inflammatory signalling 34