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Some patients report temporary fatigue, headache, or mild GI discomfort in the first 24 to 48 hours following an injection, particularly with their first dose
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A: Alternatives to estradiol patches include FDA-approved transdermal gels and sprays, oral estradiol (with a different clot-risk profile), vaginal estrogen preparations for genitourinary symptoms, and compounded transdermal estradiol creams from PCAB-accredited pharmacies
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