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Significantly, IDH2 is regulated by acetylation and deacetylation factors, where acetylation at Lys-256 reduces electrostatic repulsion, weakens ICT binding, and impairs α-ketoglutarate (α-KG) production, thereby compromising enzymatic activity (27)

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While certain foods can support glutathione production, supplementation may be beneficial, especially if you are under stress or have dietary limitations