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In a later study [108], kava treatments, either in the diet at levels of 5, 2.5 and 1.25 mg/g or by daily gavage dosing covering the initiation stage, nearly completely blocked NNK-induced lung adenoma formation in A/J mice in association with a reduction in O6-methylguanine (O6-mG), a highly tumorigenic DNA damage induced by NNK in lung tissues