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Estrogen replacement also resulted in a down-regulation of AT 1 receptors and NADPH complex in the substantia nigra, accompanied by an up-regulation of the AT 2 receptor subtype

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Research indicates that dietary supplementation with inulin can prevent ENS atrophy and dysmotility in mice with spinal cord injuries, as demonstrated by a marked restoration in the expression of the pan-neuronal marker PGP9.5 and the nitrergic neuronal enzyme (nNOS)