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He et al., 2018)
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In adult SHR, chronic ACE inhibition alleviates oxidative stress, nephrosclerosis, proteinuria, and HTN, in part by inhibiting the renal cortical advanced end-product (AGE) mediated pathway, including reductions in AGE, RAGE, Ang II, H 2 O 2 , p47phox, NF-kB p65, phosphorylated NF-kB p65, vascular cell adhesion molecule (VCAM)-1 and TGF-β1 [217]
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