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(Some medications use U-40 or higher concentrations, but U-100 is now the norm in most countries.) Insulin syringes are designed for subcutaneous (under the skin) injections and have several key features suited to this purpose: Fine, short needles: Insulin syringes use very thin needles (often 28–31 gauge) that are just a few millimeters long

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Hypertension may develop due to sodium and water retention