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In aerobic organisms, many reactive species derive from molecular oxygen, some of them are nitrogen- and sulfur-containing, or have other chemical features, for example reactive carbonyl group(s)

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The traditional way of diagnosing has been with a serum B12 blood test, however many sufferers of a B12 deficiency may not have anaemia, or have a serum B12 blood level within an abnormally low range in accordance to the ‘normal’ ranges set