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In REDEFINE 1 (overweight/obesity without T2D), CagriSema achieved mean weight reductions of 20.4-22.7% (vs 2.3-3.0% placebo) at 68 weeks, with 53.6% and 34.7% of patients achieving ≥20% and ≥25% weight loss, respectively
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Number of studies reported that repeated stress situations (social defeat, exposure to predator odor, restraint, pain conditioning, unpredictable chronic moderate stress), sleep deprivation and viral infection reduces hippocampal neurogenesis in rodents while caloric restriction, antidepressants or physical exercise increase it [77, 78]
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