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In myocardial tissue, the transmembrane fatty acid translocase CD36, which is localized in lipid rafts of the plasma membrane and interacts with caveolins, has been shown to be activated by ALP-mediated dephosphorylation of two extracellular phosphate groups of CD36, which may optimize fatty acid uptake through caveoline-dependent endocytosis [4,44,45,61]