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Cover letter should contain reason for the letter and defining terms, Management’s commitment and/or warning letter issues, addressing management responsibilities, requesting a meeting with FDA for systemic deficiencies or health risk issues, Identifying points of disagreement, Introducing appendices and commitment for next update response

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Currently, a phase II open-label clinical trial is investigating the impact of an IL-22 agonist (F-652) on AH patients [MELD (model for end-stage liver disease) scores of 11–28]