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The results directly indicated that the targeting motif RGD-binding peptide RGD-GHK almost totally suppressed the collagenase (MMP-1) expression, resisted H 2 O 2 -induced COL-1 degradation, and simultaneously promoted collagen synthesis compared with GHK alone for cell anti-aging performance
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Additionally, HIF-1α increases ceruloplasmin, which promotes the oxidation of Fe 2+ to Fe 3+ , facilitating the efflux of iron from cells (Yang et al., 2025)
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