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Dimet-Wiley, Wu, and colleagues, also publishing in Scientific Reports in 2022, found that NNMT inhibition combined with calorie restriction altered gut microbiome composition in diet-induced obese mice — suggesting systemic metabolic effects that extend beyond adipose tissue, though the clinical significance in humans is unknown

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It underscores the gap between controlled research settings and real-world use, where monitoring protocols, safety standards , and dose management may be inadequate or absent entirely

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