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The list of genes/proteins associated with IOP-induced astrogliosis comprises hundreds of genes that encode cell cycle proteins, mitogen-activated protein kinases (MAPKs), bone morphogenetic proteins (BMPs), endothelin receptors (ET A and ET B ), matrix metalloproteinases (MMPs), JAK/STAT3 transcription, cytoskeletal proteins (GFAP, vimentin, collagens, laminin and tenascin), cell adhesion components, signal transduction molecules (NF-kB, STAT5, MCP-1, glypicans), immune/complement systems (C1q, cytokines such as IL-6, LIF), periostin, phagocytosis-related gene Mac-2, and/or NF-κB-dependent assembly of the astroglial inflammasome (81, 100, 101)
