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Individual factors such as metabolic rate, body weight, and age may theoretically influence how B12 is distributed and utilised, though evidence for their impact on injection intervals is limited
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As well, some people may have allergies or medical conditions that do not allow them to be a good candidate to receive vitamin B12 shots, such as kidney problems, low potassium levels, deficiencies in other vitamins such as iron or folic acid, or just an allergy or sensitivity to vitamin B12 itself