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In particular, CRY 1 and 2 associate with a GRE in the phosphoenolpyruvate carboxykinase 1 (Pck1) promoter in a hormone-dependent manner, and dexamethasone-induced transcription of the Pck1 gene has been found increased in CRY-deficient livers 66

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It is under active investigation for heart failure, MASLD, obstructive sleep apnea (SURMOUNT-OSA), and cardiovascular outcomes in obesity