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Accelerated approval for Filspari was granted based on data from the Phase III PROTECT study, which showed that the small molecule blocker lowered urine protein levels more than three times as much as the active control, Avapro
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Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)
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