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Spermidine enhances autophagy by modulating several key signalling pathways, including the AMP-activated protein kinase (AMPK) pathway and the SIRT1 pathway, both of which are central regulators of energy metabolism, stress responses and cellular longevity (Reference Jeong, Cha and Han21)

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[30] highlighted the absence of standardized classification systems for nanomedicines, particularly in nanoparticle characterization and toxicology