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Neurological & Dopaminergic Pathways Some preclinical research has investigated BPC-157's interaction with dopaminergic and serotonergic systems, as well as its potential neuroprotective properties in brain lesion and traumatic injury models
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These challenges collectively indicate that the current understanding remains incomplete regarding the molecular mechanisms of ferroptosis are not fully understood, particularly in terms of its heterogeneous effects across different tumor types and subcellular organelles, which warrants further exploration [Table SII (277-430)] such as the impact of TME factors (oxidative stress, hypoxia and lipid metabolism) on ferroptosis susceptibility and the precise mechanisms by which ferroptosis synergizes with radioimmunotherapy, including the efficacy of radioimmunotherapy combined with ferroptosis modulation may vary significantly depending on the clinical context
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