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The multifunctional docking site of MET recruits to the plasma membrane stereotypical adaptor/signaling molecules such as Gab1, Grb2, SPH2, phosphoinositide-3-kinase (PI-3K), Src, phospholipase c gamma (PLCγ), Shc, and signal transducer and activator of transcription 3 (STAT3) (Ponzetto et al., 1994
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Frequently Asked Questions Research References Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase (Neelakantan et al., J Med Chem, 2017) Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase (Neelakantan et al., Biochem Pharmacol, 2018) Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity (Kraus et al., Nature, 2014)
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